Ontology highlight
ABSTRACT:
SUBMITTER: Broadhead MJ
PROVIDER: S-EPMC7057799 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Broadhead Matthew J MJ Miles Gareth B GB
Frontiers in cellular neuroscience 20200227
Evidence suggests that astrocytes are not merely supportive cells in the nervous system but may actively participate in the control of neural circuits underlying cognition and behavior. In this study, we examined the role of astrocytes within the motor circuitry of the mammalian spinal cord. Pharmacogenetic manipulation of astrocytic activity in isolated spinal cord preparations obtained from neonatal mice revealed astrocyte-derived, adenosinergic modulation of the frequency of rhythmic output g ...[more]