Ontology highlight
ABSTRACT:
SUBMITTER: Yokota A
PROVIDER: S-EPMC7057846 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Yokota Asumi A Huo Li L Lan Fengli F Wu Jianqiang J Huang Gang G
Molecules and cells 20200201 2
RUNX1 plays an important role in the regulation of normal hematopoiesis. <i>RUNX1</i> mutations are frequently found and have been intensively studied in hematological malignancies. Germline mutations in <i>RUNX1</i> cause familial platelet disorder with predisposition to acute myeloid leukemia (FPD/AML). Somatic mutations of <i>RUNX1</i> are observed in various types of hematological malignancies, such as AML, acute lymphoblastic leukemia (ALL), myelodysplastic syndromes (MDS), myeloproliferati ...[more]