Ontology highlight
ABSTRACT:
SUBMITTER: Silva LM
PROVIDER: S-EPMC7057911 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Silva Luciane M LM Wang Wei W Allard Bailey A BA Pottorf Tana S TS Jacobs Damon T DT Tran Pamela V PV
Methods in cell biology 20190517
Primary cilia are singular, sensory organelles that extend from the plasma membrane of most quiescent mammalian cells. These slender, microtubule-based organelles receive and transduce extracellular cues and regulate signaling pathways. Primary cilia are critical to the development and function of many tissue types, and mutation of ciliary genes causes multi-system disorders, termed ciliopathies. Notably, renal cystic disease is one of the most common clinical features of ciliopathies, highlight ...[more]