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Digoxin-amiodarone Combination is Associated With Excess All-cause Mortality in Patients With Atrial Fibrillation.


ABSTRACT: Combination use of digoxin and other medications might lead to worse outcomes in patients with atrial fibrillation (AF). We sought to investigate whether digoxin-amiodarone combination would lead to worse outcome than digoxin alone in patients with AF. Adult patients with AF and received digoxin treatment from random samples of 1,000,000 individuals covered by the National Health Insurance in Taiwan were included. Baseline characteristics including risk factors and medications were matched by propensity score (PS) in those with and without addition of amiodarone treatment. A total of 5,040 AF patients taking digoxin therapy was included. PS matching identified 1,473 patients receiving digoxin-amiodarone combination and 2,660 patients receiving digoxin with a median follow-up of 1,331 days. Digoxin-amiodarone combination was associated with increased all-cause mortality (adjusted hazard ratio (HR): 1.640, 95% confidence interval (CI): 1.470-1.829, P?

SUBMITTER: Chiang JY 

PROVIDER: S-EPMC7058044 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Digoxin-amiodarone Combination is Associated With Excess All-cause Mortality in Patients With Atrial Fibrillation.

Chiang Jiun-Yang JY   Chen Pau-Chung PC   Yang Yao-Hsu YH   Chang Chin-Hao CH   Chu Fang-Ying FY   Chen Jien-Jiun JJ   Wu Cho-Kai CK   Hwang Juey-Jen JJ   Chiang Fu-Tien FT   Lin Lian-Yu LY   Lin Jiunn-Lee JL  

Scientific reports 20200305 1


Combination use of digoxin and other medications might lead to worse outcomes in patients with atrial fibrillation (AF). We sought to investigate whether digoxin-amiodarone combination would lead to worse outcome than digoxin alone in patients with AF. Adult patients with AF and received digoxin treatment from random samples of 1,000,000 individuals covered by the National Health Insurance in Taiwan were included. Baseline characteristics including risk factors and medications were matched by pr  ...[more]

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