Ontology highlight
ABSTRACT:
SUBMITTER: Ji Q
PROVIDER: S-EPMC7058049 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Ji Qing Q Zhou Lihong L Sui Hua H Yang Liu L Wu Xinnan X Song Qing Q Jia Ru R Li Ruixiao R Sun Jian J Wang Ziyuan Z Liu Ningning N Feng Yuanyuan Y Sun Xiaoting X Cai Gang G Feng Yu Y Cai Jianfeng J Cao Yihai Y Cai Guoxiang G Wang Yan Y Li Qi Q
Nature communications 20200305 1
Tumor metastasis is a hallmark of cancer. Metastatic cancer cells often reside in distal tissues and organs in their dormant state. Mechanisms underlying the pre-metastatic niche formation are poorly understood. Here we show that in a colorectal cancer (CRC) model, primary tumors release integrin beta-like 1 (ITGBL1)-rich extracellular vesicles (EVs) to the circulation to activate resident fibroblasts in remote organs. The activated fibroblasts induce the pre-metastatic niche formation and promo ...[more]