Ontology highlight
ABSTRACT:
SUBMITTER: Van den Berge K
PROVIDER: S-EPMC7058077 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Van den Berge Koen K Roux de Bézieux Hector H Street Kelly K Saelens Wouter W Cannoodt Robrecht R Saeys Yvan Y Dudoit Sandrine S Clement Lieven L
Nature communications 20200305 1
Trajectory inference has radically enhanced single-cell RNA-seq research by enabling the study of dynamic changes in gene expression. Downstream of trajectory inference, it is vital to discover genes that are (i) associated with the lineages in the trajectory, or (ii) differentially expressed between lineages, to illuminate the underlying biological processes. Current data analysis procedures, however, either fail to exploit the continuous resolution provided by trajectory inference, or fail to ...[more]