Dataset Information

Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma.

ABSTRACT: Managing low-grade gliomas (LGG) remains a major medical challenge due to the infiltrating nature of the tumor and failure of surgical resection to eliminate the disease. EMILIN/Multimerins contain the gC1q signature, which is involved in many tumor processes. However, the expression and prognostic value of EMILIN/Multimerins in LGG remains unclear. This study used integrated bioinformatics analysis to investigate the expression pattern, prognostic value and function of EMILIN/Multimerins in patients with LGG. We analyzed the transcription levels and prognostic value EMILIN/Multimerins in LGG using the ONCOMINE, Gene Expression Profiling Interactive Analysis (GEPIA) and UALCAN databases. The mutation and co-expression rates of neighboring genes in EMILIN/Multimerins were studied using cBioPortal. TIMER and Metascape were used to reveal the potential function of EMILIN/Multimerins in LGG. According to our analysis, most EMILIN/Multimerins were overexpressed in LGG and shared a clear association with immune cells. GEPIA analysis confirmed that high levels of EMILIN/Multimerins, not including MMRN2, were associated with a poor prognosis in disease-free survival of patients with LGG. Additionally, we discovered that EMILIN/Multimerins may regulate LGG and we found a correlation between their expression patterns and distinct pathological grades. We found that EMILIN/Multimerins serve as possible prognostic biomarkers and high-priority therapeutic targets patients with LGG.

SUBMITTER: Zhao Y

PROVIDER: S-EPMC7058105 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma.

Zhao Yonghui Y Zhang Xiang X Yao Junchao J Jin Zhibin Z Liu Chen C

PeerJ 20200302

Managing low-grade gliomas (LGG) remains a major medical challenge due to the infiltrating nature of the tumor and failure of surgical resection to eliminate the disease. EMILIN/Multimerins contain the gC1q signature, which is involved in many tumor processes. However, the expression and prognostic value of EMILIN/Multimerins in LGG remains unclear. This study used integrated bioinformatics analysis to investigate the expression pattern, prognostic value and function of EMILIN/Multimerins in pat ...[more]

PMID: 32175193

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Dataset Information

Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma.

Publications

Expression patterns and the prognostic value of the EMILIN/Multimerin family members in low-grade glioma.

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