Ontology highlight
ABSTRACT:
SUBMITTER: Xu H
PROVIDER: S-EPMC7058362 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Xu Haixia H Du Xiao X Xu Jia J Zhang Yu Y Tian Yan Y Liu Geng G Wang Xiuxuan X Ma Meilin M Du Wenya W Liu Yu Y Dai Lunzhi L Huang Wendong W Tong Nanwei N Wei Yuquan Y Fu Xianghui X
PLoS biology 20200224 2
Type 2 diabetes (T2D) is characterized by insulin resistance along with pancreatic β cell failure. β cell factors are traditionally thought to control glucose homeostasis by modulating insulin levels, not insulin sensitivity. Exosomes are emerging as new regulators of intercellular communication. However, the role of β-cell-derived exosomes in metabolic homeostasis is poorly understood. Here, we report that microRNA-26a (miR-26a) in β cells not only modulates insulin secretion and β cell replica ...[more]