Ontology highlight
ABSTRACT:
SUBMITTER: Hakes AE
PROVIDER: S-EPMC7058384 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Hakes Anna E AE Brand Andrea H AH
eLife 20200219
Understanding the sequence of events leading to cancer relies in large part upon identifying the tumour cell of origin. Glioblastoma is the most malignant brain cancer but the early stages of disease progression remain elusive. Neural lineages have been implicated as cells of origin, as have glia. Interestingly, high levels of the neural stem cell regulator TLX correlate with poor patient prognosis. Here we show that high levels of the <i>Drosophila</i> TLX homologue, Tailless, initiate tumourig ...[more]