Ontology highlight
ABSTRACT:
SUBMITTER: Fan JB
PROVIDER: S-EPMC7058499 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Fan Jun-Bao JB Miyauchi Sayuri S Xu Hui-Zhong HZ Liu Dan D Kim Leo J Y LJY Burkart Christoph C Cheng Hua H Arimoto Kei-Ichiro KI Yan Ming M Zhou Yu Y Győrffy Balázs B Knobeloch Klaus-Peter KP Rich Jeremy N JN Cang Hu H Fu Xiang-Dong XD Zhang Dong-Er DE
Cancer discovery 20200123 3
Type I interferons (IFN), which activate many IFN-stimulated genes (ISG), are known to regulate tumorigenesis. However, little is known regarding how various ISGs coordinate with one another in developing antitumor effects. Here, we report that the ISG <i>UBA7</i> is a tumor suppressor in breast cancer. <i>UBA7</i> encodes an enzyme that catalyzes the covalent conjugation of the ubiquitin-like protein product of another ISG (<i>ISG15</i>) to cellular proteins in a process known as "ISGylation." ...[more]