Ontology highlight
ABSTRACT:
SUBMITTER: Keo A
PROVIDER: S-EPMC7058608 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Keo Arlin A Mahfouz Ahmed A Ingrassia Angela M T AMT Meneboo Jean-Pascal JP Villenet Celine C Mutez Eugénie E Comptdaer Thomas T Lelieveldt Boudewijn P F BPF Figeac Martin M Chartier-Harlin Marie-Christine MC van de Berg Wilma D J WDJ van Hilten Jacobus J JJ Reinders Marcel J T MJT
Communications biology 20200305 1
The molecular mechanisms underlying caudal-to-rostral progression of Lewy body pathology in Parkinson's disease remain poorly understood. Here, we identified transcriptomic signatures across brain regions involved in Braak Lewy body stages in non-neurological adults from the Allen Human Brain Atlas. Among the genes that are indicative of regional vulnerability, we found known genetic risk factors for Parkinson's disease: SCARB2, ELOVL7, SH3GL2, SNCA, BAP1, and ZNF184. Results were confirmed in t ...[more]