Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy.
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ABSTRACT:
SUBMITTER: Zhang J
PROVIDER: S-EPMC7058798 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
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Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy.
Zhang Jiaqi J Zhao Licong L Hu Cheng C Wang Tao T Lu Juan J Wu Chenqu C Chen Long L Jin Mingming M Hu Hao H Ji Guang G Cao Qin Q Jiang Yuanye Y
Frontiers in pharmacology 20200228
Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury <i>in vitro</i> and <i>vivo</i>. Assessment of mouse serum levels of alanine/aspartate aminotransferases (ALT/AST), liver myeloperoxidase (MPO) activity, malondialdehyde (MDA), glutathione (GSH ...[more]
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