Ontology highlight
ABSTRACT:
SUBMITTER: Faigenbaum-Romm R
PROVIDER: S-EPMC7059120 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Cell reports 20200301 9
Bacterial small RNAs (sRNAs) are posttranscriptional regulators of gene expression that base pair with complementary sequences on target mRNAs, often in association with the chaperone Hfq. Here, using experimentally identified sRNA-target pairs, along with gene expression measurements, we assess basic principles of regulation by sRNAs. We show that the sRNA sequence dictates the target repertoire, as point mutations in the sRNA shift the target set correspondingly. We distinguish two subsets of ...[more]