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Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma.


ABSTRACT: Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here presented first report about successful allogeneic hematopoietic stem cell transplantation leading to remission in a case of tonsillar MCS represents a promising potential curative treatment option for this rare and often fatal disease.

SUBMITTER: Kubasch AS 

PROVIDER: S-EPMC7059127 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Allogeneic Hematopoietic Stem Cell Transplantation in a Rare Case of Tonsillar Mast Cell Sarcoma.

Kubasch Anne Sophie AS   Franke Georg-Nikolaus GN   Aldaoud Ali A   Weibl Konstantin K   Jentzsch Madlen M   Sabri Osama O   Horny Hans-Peter HP   Fend Falko F   Behre Gerhard G   Platzbecker Uwe U   Vucinic Vladan V  

Frontiers in oncology 20200228


Mast cell sarcoma comprises a rare aggressive mast cell neoplasia with histological, clinical, and genetic features distinct from other mast cell neoplasm. Until now, prognosis is still poor due to high rates of progression to mast cell leukemia and failure of conventional chemotherapies. Our here presented first report about successful allogeneic hematopoietic stem cell transplantation leading to remission in a case of tonsillar MCS represents a promising potential curative treatment option for  ...[more]

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