Ontology highlight
ABSTRACT:
SUBMITTER: Guderyon MJ
PROVIDER: S-EPMC7059148 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Guderyon Michael J MJ Chen Cang C Bhattacharjee Anindita A Ge Guo G Fernandez Roman A RA Gelfond Jonathan A L JAL Gorena Karla M KM Cheng Catherine J CJ Li Yang Y Nelson James F JF Strong Randy J RJ Hornsby Peter J PJ Clark Robert A RA Li Senlin S
Aging cell 20200203 3
Mammalian aging is associated with reduced tissue regeneration and loss of physiological integrity. With age, stem cells diminish in their ability to regenerate adult tissues, likely contributing to age-related morbidity. Thus, we replaced aged hematopoietic stem cells (HSCs) with young-donor HSCs using a novel mobilization-enabled hematopoietic stem cell transplantation (HSCT) technology as an alternative to the highly toxic conditioning regimens used in conventional HSCT. Using this approach, ...[more]