Ontology highlight
ABSTRACT:
SUBMITTER: Pecoraro A
PROVIDER: S-EPMC7059194 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Pecoraro Antonio A Crescenzi Ludovica L Varricchi Gilda G Marone Giancarlo G Spadaro Giuseppe G
Frontiers in immunology 20200228
Common variable immunodeficiency (CVID) is the most frequent primary immunodeficiency (PID) in adulthood and is characterized by severe reduction of immunoglobulin serum levels and impaired antibody production in response to vaccines and pathogens. Beyond the susceptibility to infections, CVID encompasses a wide spectrum of clinical manifestations related to a complex immune dysregulation that also affects liver. Although about 50% CVID patients present persistently deranged liver function, burd ...[more]