Synthesis and herbicidal activities of aryloxyacetic acid derivatives as HPPD inhibitors.

ABSTRACT: A series of aryloxyacetic acid derivatives were designed and synthesized as 4-hydoxyphenylpyruvate dioxygenase (HPPD) inhibitors. Preliminary bioassay results reveal that these derivatives are promising Arabidopsis thaliana HPPD (AtHPPD) inhibitors, in particular compounds I12 (K _i = 0.011 µM) and I23 (K _i = 0.012 µM), which exhibit similar activities to that of mesotrione, a commercial HPPD herbicide (K _i = 0.013 µM). Furthermore, the newly synthesized compounds show significant greenhouse herbicidal activities against tested weeds at dosages of 150 g ai/ha. In particular, II4 exhibited high herbicidal activity for pre-emergence treatment that was slightly better than that of mesotrione. In addition,

SUBMITTER: Wang MM 

PROVIDER: S-EPMC7059547 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature