Ontology highlight
ABSTRACT:
SUBMITTER: Stafford WC
PROVIDER: S-EPMC7059553 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Stafford William C WC Peng Xiaoxiao X Olofsson Maria Hägg MH Zhang Xiaonan X Luci Diane K DK Lu Li L Cheng Qing Q Trésaugues Lionel L Dexheimer Thomas S TS Coussens Nathan P NP Augsten Martin M Ahlzén Hanna-Stina Martinsson HM Orwar Owe O Östman Arne A Stone-Elander Sharon S Maloney David J DJ Jadhav Ajit A Simeonov Anton A Linder Stig S Arnér Elias S J ESJ
Science translational medicine 20180201 428
Cancer cells adapt to their inherently increased oxidative stress through activation of the glutathione (GSH) and thioredoxin (TXN) systems. Inhibition of both of these systems effectively kills cancer cells, but such broad inhibition of antioxidant activity also kills normal cells, which is highly unwanted in a clinical setting. We therefore evaluated targeting of the TXN pathway alone and, more specifically, selective inhibition of the cytosolic selenocysteine-containing enzyme TXN reductase 1 ...[more]