Unknown

Dataset Information

0

Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy.


ABSTRACT: The development of the nanosized delivery systems with targeting navigation and efficient cargo release for cancer therapy has attracted great attention in recent years. Herein, a folic acid (FA) modified PEGylated polycaprolactone containing ditelluride linkage was synthesized through a facile coupling reaction. The hydrophobic doxorubicin (DOX) can be encapsulated into the polymeric micelles, and such nanoparticles (F-TeNPDOX) exhibited redox-responsive drug release under abundant glutathione (GSH) condition due to the degradation of ditelluride bonds. In addition, flow cytometric analyses showed that the FA ligands on F-TeNPDOX could facilitate their cellular uptake in 4T1 breast cancer cells. Therefore, F-TeNPDOX led to the promoted drug accumulation and enhanced growth inhibition on 4T1 tumor in vivo. The obtained results suggest F-TeNPDOX excellent potential as nanocarriers for anticancer drug delivery.

SUBMITTER: Pang Z 

PROVIDER: S-EPMC7059598 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

altmetric image

Publications

Ditelluride-Bridged PEG-PCL Copolymer as Folic Acid-Targeted and Redox-Responsive Nanoparticles for Enhanced Cancer Therapy.

Pang Zekun Z   Zhou Jiayan J   Sun Chunyang C  

Frontiers in chemistry 20200228


The development of the nanosized delivery systems with targeting navigation and efficient cargo release for cancer therapy has attracted great attention in recent years. Herein, a folic acid (FA) modified PEGylated polycaprolactone containing ditelluride linkage was synthesized through a facile coupling reaction. The hydrophobic doxorubicin (DOX) can be encapsulated into the polymeric micelles, and such nanoparticles (F-TeNP<sub>DOX</sub>) exhibited redox-responsive drug release under abundant g  ...[more]

Similar Datasets

| S-EPMC6749289 | biostudies-literature
| S-EPMC6572280 | biostudies-literature
| S-EPMC8428179 | biostudies-literature
| S-EPMC7023447 | biostudies-literature
| S-EPMC5125786 | biostudies-literature
| S-EPMC4747216 | biostudies-other
| S-EPMC9823996 | biostudies-literature
| S-EPMC6854260 | biostudies-literature
| S-EPMC6695667 | biostudies-literature
| S-EPMC4755322 | biostudies-literature