Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC7059699 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Liu Shui S Yang Xiaofeng X Zhang Hong H Zhang Jian J Zhou Yonglin Y Wang Tingting T Hu Naiyu N Deng Xuming X Bai Xiaoxue X Wang Jianfeng J
Frontiers in pharmacology 20200228
<i>Clostridium perfringens</i> (<i>C. perfringens</i>) type A strains are the main cause of gas gangrene in humans and animals. Treatment of this lethal disease is limited, and the prognosis is not good. Alpha-toxin (CPA) and perfringolysin O (PFO) secreted by <i>C. perfringens</i> play irreplaceable roles in cytotoxicity to host cells, persistence in host tissues, and lethality of gas gangrene pathology. This work determined the influence of amentoflavone, a biflavonoid isolated from <i>Selagin ...[more]