The relation between crosstalk and gene regulation form revisited.

ABSTRACT: Genes differ in the frequency at which they are expressed and in the form of regulation used to control their activity. In particular, positive or negative regulation can lead to activation of a gene in response to an external signal. Previous works proposed that the form of regulation of a gene correlates with its frequency of usage: positive regulation when the gene is frequently expressed and negative regulation when infrequently expressed. Such network design means that, in the absence of their regulators, the genes are found in their least required activity state, hence regulatory intervention is often necessary. Due to the multitude of genes and regulators, spurious binding and unbinding events, called "crosstalk", could occur. To determine how the form of regulation affects the glob

SUBMITTER: Grah R 

PROVIDER: S-EPMC7059967 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature