Ontology highlight
ABSTRACT:
SUBMITTER: Heng YJ
PROVIDER: S-EPMC7060119 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Heng Yujing J YJ Hankinson Susan E SE Wang Jun J Alexandrov Ludmil B LB Ambrosone Christine B CB de Andrade Victor P VP Brufsky Adam M AM Couch Fergus J FJ King Tari A TA Modugno Francesmary F Vachon Celine M CM Eliassen A Heather AH Tamimi Rulla M RM Kraft Peter P
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20200113 3
<h4>Background</h4>The link between modifiable breast cancer risk factors and tumor genomic alterations remains largely unexplored. We evaluated the association of prediagnostic body mass index (BMI), cigarette smoking, and alcohol consumption with somatic copy number variation (SCNV), total somatic mutation burden (TSMB), seven single base substitution (SBS) signatures (SBS1, SBS2, SBS3, SBS5, SBS13, SBS29, and SBS30), and nine driver mutations (<i>CDH1, GATA3, KMT2C, MAP2K4, MAP3K1, NCOR1, PIK ...[more]