Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape.
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ABSTRACT:
SUBMITTER: Wu NC
PROVIDER: S-EPMC7060233 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Major antigenic site B of human influenza H3N2 viruses has an evolving local fitness landscape.
Wu Nicholas C NC Otwinowski Jakub J Thompson Andrew J AJ Nycholat Corwin M CM Nourmohammad Armita A Wilson Ian A IA
Nature communications 20200306 1
Antigenic drift of influenza virus hemagglutinin (HA) is enabled by facile evolvability. However, HA antigenic site B, which has become immunodominant in recent human H3N2 influenza viruses, is also evolutionarily constrained by its involvement in receptor binding. Here, we employ deep mutational scanning to probe the local fitness landscape of HA antigenic site B in six different human H3N2 strains spanning from 1968 to 2016. We observe that the fitness landscape of HA antigenic site B can be v ...[more]
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