Ontology highlight
ABSTRACT:
SUBMITTER: Hajam IA
PROVIDER: S-EPMC7060564 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Hajam Irshad Ahmed IA Senevirathne Amal A Hewawaduge Chamit C Kim Jehyoung J Lee John Hwa JH
Veterinary research 20200306 1
Chitosan nanoparticles (CNPs) represent an efficient vaccination tool to deliver immunogenic antigens to the antigen-presenting cells (APCs), which subsequently stimulate protective immune responses against infectious diseases. Herein, we prepared CNPs encapsulating mRNA molecules followed by surface coating with conserved H9N2 HA2 and M2e influenza proteins. We demonstrated that CNPs efficiently delivered mRNA molecules into APCs and had effectively penetrated the mucosal barrier to reach to th ...[more]