Health-related quality of life in hereditary transthyretin amyloidosis polyneuropathy: a prospective, observational study.

ABSTRACT:

Background

Hereditary Transthyretin Amyloidosis Polyneuropathy is a rare life-threatening neurologic disease that imposes considerable mortality and it is associated with progressive related disabilities. In this study, we aimed to assess the effect of the disease across health-related quality of life dimensions, in both carriers of the mutation and patients, to compare health-related quality of life with general population, as well as to explore health-related quality of life prognostic factors among patients, including disease progression and treatment.

Methods

This study was a multi-institutional, longitudinal, prospective, observational study of hereditary Transthyretin Amyloidosis Polyneuropathy Portuguese adult subjects (621 asymptomatic carriers and 733 symptomatic pa

SUBMITTER: Ines M 

PROVIDER: S-EPMC7060628 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature