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Combining the Fibrinogen/Albumin Ratio and Systemic Inflammation Response Index Predicts Survival in Resectable Gastric Cancer.


ABSTRACT: Aims:Predicting the prognosis of gastric cancer using tumour-node-metastasis (TNM) staging is difficult as patients with the same TNM stage exhibit different prognoses. Methods:This study investigated the prognostic value of the preoperative fibrinogen/albumin ratio (FAR)-systemic inflammation response index (SIRI) score in resectable gastric cancer (rGC). Results:Clinicopathological features of 231 rGC patients were analysed retrospectively. Patients were divided into three groups: FAR-SIRI score 2 (FAR ? 0.071 and SIRI ? 0.84), 1 (FAR < 0.071 and SIRI ? 0.84), and 0 (SIRI < 0.84). Higher FAR-SIRI scores were associated with larger tumours, poorer differentiation, and advanced TNM stage (P < 0.05). Compared to those with FAR-SIRI scores of 0, patients with scores of 2 had poorer overall survival (OS). The FAR-SIRI score was an independent prognostic factor for OS in rGC. Conclusion:The present data demonstrated that FAR-SIRI scores predicted radical gastric cancer surgical outcomes and may serve as a blood marker for identifying high-risk patients.

SUBMITTER: Zhang J 

PROVIDER: S-EPMC7060846 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Combining the Fibrinogen/Albumin Ratio and Systemic Inflammation Response Index Predicts Survival in Resectable Gastric Cancer.

Zhang Junbin J   Ding Yongfeng Y   Wang Weibin W   Lu Yimin Y   Wang Haiyong H   Wang Haohao H   Teng Lisong L  

Gastroenterology research and practice 20200225


<h4>Aims</h4>Predicting the prognosis of gastric cancer using tumour-node-metastasis (TNM) staging is difficult as patients with the same TNM stage exhibit different prognoses.<h4>Methods</h4>This study investigated the prognostic value of the preoperative fibrinogen/albumin ratio (FAR)-systemic inflammation response index (SIRI) score in resectable gastric cancer (rGC).<h4>Results</h4>Clinicopathological features of 231 rGC patients were analysed retrospectively. Patients were divided into thre  ...[more]

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