Dataset Information

High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.

ABSTRACT: TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between TXLNA and tumorigenesis and progression of pancreatic adenocarcinoma (PAAD) is still unclear. The present study was designed to examine the expression profile of TXLNA and explore its prognostic significance in PAAD patients and the possible molecular regulatory mechanism by analyzing a series of data from databases, including GEPIA, LOGpc, STRING, and GeneMANIA. The results indicate that TXLNA mRNA and protein were remarkably increased in PAAD tissues compared with normal pancreatic tissues. The high TXLNA expression was significantly correlated with superior overall survival (OS), disease-free interval (DFI), disease specific survival (DSS), and progression-free interval (PFI) for PAAD patients. In summary, high TXLNA expression could predict favourable OS, DFI, DSS, and PFI for PAAD patients, and it might be as potential prognostic biomarkers and targets for PAAD.

SUBMITTER: Lv S

PROVIDER: S-EPMC7060861 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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High <i>TXLNA</i> Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.

Lv Shuangyu S Zhang Guosen G Xie Longxiang L Yan Zhongyi Z Wang Qiang Q Li Yongqiang Y Zhang Lu L Han Yali Y Li Huimin H Du Yaowu Y Yang Yanjie Y Guo Xiangqian X

BioMed research international 20200225

TXLNA (taxilin alpha), a binding partner of the syntaxin family, was identified as a key factor in the coordination of intracellular vesicle trafficking and highly expressed in various tumor cells. However, the accurate relation between TXLNA and tumorigenesis and progression of pancreatic adenocarcinoma (PAAD) is still unclear. The present study was designed to examine the expression profile of TXLNA and explore its prognostic significance in PAAD patients and the possible molecular regulatory ...[more]

PMID: 32185195

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Dataset Information

High TXLNA Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.

Publications

High <i>TXLNA</i> Expression Predicts Favourable Outcome for Pancreatic Adenocarcinoma Patients.

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