Ontology highlight
ABSTRACT:
SUBMITTER: Khadjeh S
PROVIDER: S-EPMC7060963 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Khadjeh Sara S Hindmarsh Vanessa V Weber Frederike F Cyganek Lukas L Vidal Ramon O RO Torkieh Setare S Streckfuss-Bömeke Katrin K Lbik Dawid D Tiburcy Malte M Mohamed Belal A BA Bonn Stefan S Toischer Karl K Hasenfuss Gerd G
Basic research in cardiology 20200307 3
Heart failure is a major health problem worldwide with a significant morbidity and mortality rate. Although studied extensively in animal models, data from patients at the compensated disease stage are lacking. We sampled myocardium biopsies from aortic stenosis patients with compensated hypertrophy and moderate heart failure and used transcriptomics to study the transition to failure. Sequencing and comparative analysis of analogous samples of mice with transverse aortic constriction identified ...[more]