Ontology highlight
ABSTRACT:
SUBMITTER: Clark SL
PROVIDER: S-EPMC7061076 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Clark Shaunna L SL Hattab Mohammad W MW Chan Robin F RF Shabalin Andrey A AA Han Laura K M LKM Zhao Min M Smit Johannes H JH Jansen Rick R Milaneschi Yuri Y Xie Lin Ying LY van Grootheest Gerard G Penninx Brenda W J H BWJH Aberg Karolina A KA van den Oord Edwin J C G EJCG
Molecular psychiatry 20190909 6
Recurrent and chronic major depressive disorder (MDD) accounts for a substantial part of the disease burden because this course is most prevalent and typically requires long-term treatment. We associated blood DNA methylation profiles from 581 MDD patients at baseline with MDD status 6 years later. A resampling approach showed a highly significant association between methylation profiles in blood at baseline and future disease status (P = 2.0 × 10<sup>-16</sup>). Top MWAS results were enriched s ...[more]