Dataset Information

Resolution-based spectral clustering for brain parcellation using functional MRI.

ABSTRACT: BACKGROUND:Brain parcellation is important for exploiting neuroimaging data. Variability in physiology between individuals has led to the need for data-driven approaches to parcellation, with recent research focusing on simultaneously estimating and partitioning the network structure of the brain. NEW METHOD:We view data preprocessing, parcellation, and parcel validation from the perspective of predictive modeling. The goal is to identify parcels in a way that best generalizes to unseen data. We utilize an uncertainty quantification approach from image science to define parcels as groups of unresolvable variables in the predictive model. Model parameters are chosen via cross-validation. Parcellation results are compared based on both their repeatability as well as their ability to describe held-out data. RESULTS:The approach provides insight and strategies for open questions such as the choice of evaluation metrics, selection of model order, and the optimal tuning of preprocessing steps for functional imaging data. COMPARISON WITH EXISTING METHODS:We compare new and established approaches using functional imaging data, where we find the proposed approach produces parcellations which are both more accurate and more repeatable than the current baseline clustering method. The metrics also demonstrate potential problems with overfitting for the baseline method, and with bias for other methods. CONCLUSIONS:Clustering of resolution provides a principled and robust approach to brain parcellation which improves on the current baseline.

SUBMITTER: Dillon K

PROVIDER: S-EPMC7061089 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Specialized processing in the brain is performed by multiple groups of brain regions organized as functional modules. Although, in vivo studies of brain functional modules involve multiple functional Magnetic Resonance Imaging (fMRI) scans, the methods used to derive functional modules from functional networks of the brain ignore individual differences in the functional architecture and use incomplete functional connectivity information. To correct this, we propose an Iterative Consensus Spectral Clustering (ICSC) algorithm that detects the most representative modules from individual dense weighted connectivity matrices derived from multiple scans. The ICSC algorithm derives group-level modules from modules of multiple individuals by iteratively minimizing the consensus-cost between the two. We demonstrate that the ICSC algorithm can be used to derive biologically plausible group-level (for multiple subjects) and subject-level (for multiple subject scans) brain modules, using resting-state fMRI scans of 589 subjects from the Human Connectome Project. We employed a multipronged strategy to show the validity of the modularizations obtained from the ICSC algorithm. We show a heterogeneous variability in the modular structure across subjects where modules involved in visual and motor processing were highly stable across subjects. Conversely, we found a lower variability across scans of the same subject. The performance of our algorithm was compared with existing functional brain modularization methods and we show that our method detects group-level modules that are more representative of the modules of multiple individuals. Finally, the experiments on synthetic images quantitatively demonstrate that the ICSC algorithm detects group-level and subject-level modules accurately under varied conditions. Therefore, besides identifying functional modules for a population of subjects, the proposed method can be used for applications in personalized neuroscience. The ICSC implementation is available at https://github.com/SCSE-Biomedical-Computing-Group/ICSC.

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Resolution-based spectral clustering for brain parcellation using functional MRI.

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