Ontology highlight
ABSTRACT:
SUBMITTER: Struckman HL
PROVIDER: S-EPMC7061261 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Struckman Heather L HL Baine Stephen S Thomas Justin J Mezache Louisa L Mykytyn Kirk K Györke Sándor S Radwański Przemysław B PB Veeraraghavan Rengasayee R
Microscopy and microanalysis : the official journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada 20200201 1
The voltage-gated sodium channel [pore-forming subunit of the neuronal voltage-gated sodium channel (NaV1.6)] has recently been found in cardiac myocytes. Emerging studies indicate a role for NaV1.6 in ionic homeostasis as well as arrhythmogenesis. Little is known about the spatial organization of these channels in cardiac muscle, mainly due to the lack of high-fidelity antibodies. Therefore, we developed and rigorously validated a novel rabbit polyclonal NaV1.6 antibody and undertook super-reso ...[more]