State of Type 1 Diabetes Management and Outcomes from the T1D Exchange in 2016-2018.

ABSTRACT:

Objective

To provide a snapshot of the profile of adults and youth with type 1 diabetes (T1D) in the United States and assessment of longitudinal changes in T1D management and clinical outcomes in the T1D Exchange registry.

Research design and methods

Data on diabetes management and outcomes from 22,697 registry participants (age 1-93 years) were collected between 2016 and 2018 and compared with data collected in 2010-2012 for 25,529 registry participants.

Results

Mean HbA1c in 2016-2018 increased from 65?mmol/mol at the age of 5 years to 78?mmol/mol between ages 15 and 18, with a decrease to 64?mmol/mol by age 28 and 58-63?mmol/mol beyond age 30. The American Diabetes Association (ADA) HbA1c goal of <58?mmol/mol for youth was achieved by only 17% and the goal of <53?mmol/mol for adults by only 21%. Mean HbA1c levels changed little between 2010-2012 and 2016-2018, except in adolescents who had a higher mean HbA1c in 2016-2018. Insulin pump use increased from 57% in 2010-2012 to 63% in 2016-2018. Continuous glucose monitoring (CGM) increased from 7% in 2010-2012 to 30% in 2016-2018, rising >10-fold in children <12 years old. HbA1c levels were lower in CGM users than nonusers. Severe hypoglycemia was most frequent in participants ?50 years old and diabetic ketoacidosis was most common in adolescents and young adults. Racial differences were evident in use of pumps and CGM and HbA1c levels.

Conclusions

Data from the T1D Exchange registry demonstrate that only a minority of adults and youth with T1D in the United States achieve ADA goals for HbA1c.

SUBMITTER: Foster NC 

PROVIDER: S-EPMC7061293 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature