Ontology highlight
ABSTRACT:
SUBMITTER: Chefetz I
PROVIDER: S-EPMC7061440 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chefetz Ilana I Grimley Edward E Yang Kun K Hong Linda L Vinogradova Ekaterina V EV Suciu Radu R Kovalenko Ilya I Karnak David D Morgan Cynthia A CA Chtcherbinine Mikhail M Buchman Cameron C Huddle Brandt B Barraza Scott S Morgan Meredith M Bernstein Kara A KA Yoon Euisik E Lombard David B DB Bild Andrea A Mehta Geeta G Romero Iris I Chiang Chun-Yi CY Landen Charles C Cravatt Benjamin B Hurley Thomas D TD Larsen Scott D SD Buckanovich Ronald J RJ
Cell reports 20190301 11
Ovarian cancer is typified by the development of chemotherapy resistance. Chemotherapy resistance is associated with high aldehyde dehydrogenase (ALDH) enzymatic activity, increased cancer "stemness," and expression of the stem cell marker CD133. As such, ALDH activity has been proposed as a therapeutic target. Although it remains controversial which of the 19 ALDH family members drive chemotherapy resistance, ALDH1A family members have been primarily linked with chemotherapy resistant and stemn ...[more]