Dataset Information

A modified technique for securing drains to the skin.

ABSTRACT: There is a wide range of surgical procedures that require placement of drains. It is important to ensure that the drains remain in the correct position until their removal. The classic method for fixing drains to the skin involves the use of surgical knots. Typically, one or more of them are tied directly to the skin surface, close to the drain exit site, so potentially giving rise to problems involving tissue damage or the development of obvious scars, if the knots are excessively tight around the skin. With the drain fixation technique that we developed none of the knots constricts the skin, so avoiding any kind of damage to it.

SUBMITTER: Mura S

PROVIDER: S-EPMC7061563 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

A modified technique for securing drains to the skin.

Mura Sebastiano S Guarneri Gianni Franco GF Parodi Pier Camillo PC

JPRAS open 20180623

There is a wide range of surgical procedures that require placement of drains. It is important to ensure that the drains remain in the correct position until their removal. The classic method for fixing drains to the skin involves the use of surgical knots. Typically, one or more of them are tied directly to the skin surface, close to the drain exit site, so potentially giving rise to problems involving tissue damage or the development of obvious scars, if the knots are excessively tight around ...[more]

PMID: 32158827

Similar Datasets

Project description:BackgroundMonitoring the effects of biologic therapies in skin diseases will benefit from alternative noninvasive skin sampling techniques to evaluate immune pathways in diseased tissue early and longitudinally.ObjectiveTo establish a minimally invasive profiling of skin cytokines for diagnosis, therapeutic response monitoring, and clinical research in atopic dermatitis (AD) and other skin diseases, particularly in pediatric cohorts.MethodsWe developed a novel method for cytokine profiling in the epidermis using skin tape strips (STSs) in a setting designed to maximize the efficiency of protein extraction from STSs. This method was applied to analyze STS protein extracts from the lesional skin of children having AD (n = 41) and normal, healthy controls (n = 22). A total of 20 cytokines were probed with the ultrasensitive Mesoscale multiplex cytokine assay.ResultsA significant increase in interleukin (IL)-1b (P < .01), IL-18 (P < .001), and IL-8 (P < .001) with a decrease in IL-1a (P < .001) in the stratum corneum of AD lesional skin was found. Concurrently, an increase in markers associated with type 2 inflammatory response was readily detectable in AD lesional skin, including C-C motif chemokine ligand (CCL) 22, CCL 17, and thymic stromal lymphopoietin (TSLP). The levels of IL-1b, IL-18, and TSLP exhibited positive correlations with the AD severity index (Scoring AD index) and skin transepidermal water loss (TEWL), whereas an inverse correlation between IL-1a and Scoring AD index and IL-1a and TEWL was found. The levels of CCL17, CCL22, TSLP, IL-22, and IL-17a correlated with skin TEWL measurements.ConclusionUsing minimally invasive STS analysis, we identified cytokine profiles easily sampled in AD lesional skin. The expression of these markers correlated with disease severity and reflected changes in TEWL in lesional skin. These markers suggest new response assessment targets for AD skin.Trial registrationClinicalTrials.gov Identifier: NCT03168113.

Dataset Information

A modified technique for securing drains to the skin.

Publications

A modified technique for securing drains to the skin.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets