A fluorescent hydrazone exchange probe of pyridoxal phosphate for the assessment of vitamin B6 status.

ABSTRACT: Abnormal vitamin B6 status, marked by deficient intracellular concentrations of pyridoxal phosphate (PLP), is classified as a direct biomarker based on its biomedical significance. However, there exist no direct methods for measuring vitamin B6 status in intact cells. Here we describe the development of a fluorogenic probe, RAB6, which shows remarkable selectivity for PLP among the B6 vitamers and other cellular aldehydes.

SUBMITTER: Jun YW 

PROVIDER: S-EPMC7061904 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature