Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Axisymmetric scalable magneto-gravitational trap for diamagnetic particle levitation.

ABSTRACT: We report on the design, construction, and use of axisymmetric magnetic traps for levitating diamagnetic particles. The magnetic traps each consist of two pole pieces passively driven by a neodymium iron boron (NdFeB) permanent magnet. The magnetic field configuration between the pole pieces combined with the earth's gravitational field forms a 3D confining potential capable of levitating a range of diamagnetic substances, e.g., graphite powder, silica microspheres, and gallium nitride (GaN) powder and nanowires. Particles trap stably at atmosphere and in high-vacuum for periods up to weeks with lifetimes largely determined by choices made to actively destabilize the trap. We describe the principles of operation, finite element design, approximate closed-form results for design rules, and examples of operation of such traps.

SUBMITTER: Houlton JP

PROVIDER: S-EPMC7061913 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Publications

Axisymmetric scalable magneto-gravitational trap for diamagnetic particle levitation.

Houlton J P JP Chen M L ML Brubaker M D MD Bertness K A KA Rogers C T CT

The Review of scientific instruments 20181201 12

We report on the design, construction, and use of axisymmetric magnetic traps for levitating diamagnetic particles. The magnetic traps each consist of two pole pieces passively driven by a neodymium iron boron (NdFeB) permanent magnet. The magnetic field configuration between the pole pieces combined with the earth's gravitational field forms a 3D confining potential capable of levitating a range of diamagnetic substances, e.g., graphite powder, silica microspheres, and gallium nitride (GaN) pow ...[more]

PMID: 30599595

Similar Datasets

Cooling the Motion of Diamond Nanocrystals in a Magneto-Gravitational Trap in High Vacuum.

Project description:Levitated diamond nanocrystals with nitrogen-vacancy (NV) centres in high vacuum have been proposed as a unique system for experiments in fundamental quantum mechanics, including the generation of large quantum superposition states and tests of quantum gravity. This system promises extreme isolation from its environment while providing quantum control and sensing through the NV centre spin. While optical trapping has been the most explored method of levitation, recent results indicate that excessive optical heating of the nanodiamonds under vacuum may make the method impractical with currently available materials. Here, we study an alternative magneto-gravitational trap for diamagnetic particles, such as diamond nanocrystals, with stable levitation from atmospheric pressure to high vacuum. Magnetic field gradients from permanent magnets confine the particle in two dimensions, while confinement in the third dimension is gravitational. We demonstrate that feedback cooling of the centre-of-mass motion of a trapped nanodiamond cluster results in cooling of one degree of freedom to less than 1?K.

| S-EPMC4957077 | biostudies-literature

Magneto-Driven Gradients of Diamagnetic Objects for Engineering Complex Tissues.

Project description:Engineering complex tissues represents an extraordinary challenge and, to date, there have been few strategies developed that can easily recapitulate native-like cell and biofactor gradients in 3D materials. This is true despite the fact that mimicry of these gradients may be essential for the functionality of engineered graft tissues. Here, a non-traditional magnetics-based approach is developed to predictably position naturally diamagnetic objects in 3D hydrogels. Rather than magnetizing the objects within the hydrogel, the magnetic susceptibility of the surrounding hydrogel precursor solution is enhanced. In this way, a range of diamagnetic objects (e.g., polystyrene beads, drug delivery microcapsules, and living cells) are patterned in response to a brief exposure to a magnetic field. Upon photo-crosslinking the hydrogel precursor, object positioning is maintained, and the magnetic contrast agent diffuses out of the hydrogel, supporting long-term construct viability. This approach is applied to engineer cartilage constructs with a depth-dependent cellularity mirroring that of native tissue. These are thought to be the first results showing that magnetically unaltered cells can be magneto-patterned in hydrogels and cultured to generate heterogeneous tissues. This work provides a foundation for the formation of opposing magnetic-susceptibility-based gradients within a single continuous material.

| S-EPMC7723011 | biostudies-literature

Blockage of hemichannels alters gene expression in osteocytes in a high magneto-gravitational environment

2016-08-24 | GSE85968 | GEO

Three-dimensional diamagnetic particle deflection in ferrofluid microchannel flows.

Project description:Magnetic field-induced particle manipulation is a promising technique for biomicrofluidics applications. It is simple, cheap, and also free of fluid heating issues that accompany other common electric, acoustic, and optical methods. This work presents a fundamental study of diamagnetic particle motion in ferrofluid flows through a rectangular microchannel with a nearby permanent magnet. Due to their negligible magnetization relative to the ferrofluid, diamagnetic particles experience negative magnetophoresis and are repelled away from the magnet. The result is a three-dimensionally focused particle stream flowing near the bottom outer corner of the microchannel that is the farthest to the center of the magnet and hence has the smallest magnetic field. The effects of the particle's relative position to the magnet, particle size, ferrofluid flow rate, and concentration on this three-dimensional diamagnetic particle deflection are systematically studied. The obtained experimental results agree quantitatively with the predictions of a three-dimensional analytical model.

| S-EPMC3364825 | biostudies-other

Blockage of hemichannels alters gene expression in osteocytes in a high magneto-gravitational environment.

Project description:Osteocytes, the most abundant cells in bone, are highly responsive to external environmental changes. We tested how Cx43 hemichannels which mediate the exchange of small molecules between cells and extracellular environment impact genome wide gene expression under conditions of abnormal gravity and magnetic field. To this end, we subjected osteocytic MLO-Y4 cells to a high magneto-gravitational environment and used microarray to examine global gene expression and a specific blocking antibody was used to assess the role of Cx43 hemichannels. While 3 hr exposure to abnormal gravity and magnetic field had relatively minor effects on global gene expression, blocking hemichannels significantly impacted the expression of a number of genes which are involved in cell viability, apoptosis, mineral absorption, protein absorption and digestion, and focal adhesion. Also, blocking of hemichannels enriched genes in multiple signaling pathways which are enaged by TGF-beta, Jak-STAT and VEGF. These results show the role of connexin hemichannels in bone cells in high magneto-gravitational environments.

| S-EPMC5726265 | biostudies-literature

Blockage of hemichannels alters gene expression in osteocytes in a high magneto-gravitational environment

Project description:We tested how Cx43 hemichannels which mediate the exchange of small molecules between cells and extracellular environment impact genome wide gene expression under conditions of abnormal gravity and magnetic field. we subjected osteocytic MLO-Y4 cells to a high magneto-gravitational environment and used microarray to examine global gene expression and a specific blocking antibody was used to assess the role of Cx43 hemichannels. Microarray analysis was conducted to identify the alterations of global gene expression profile of osteocytic MLO-Y4 cells under HMGE. Furthermore, the effects of Cx43 hemichannels on gene expression were investigated by using a potent, Cx43 hemichannel-blocking antibody Cx43(E2)

2016-08-24 | E-GEOD-85968 | biostudies-arrayexpress

Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster.

Project description:BACKGROUND: Many biological systems respond to the presence or absence of gravity. Since experiments performed in space are expensive and can only be undertaken infrequently, Earth-based simulation techniques are used to investigate the biological response to weightlessness. A high gradient magnetic field can be used to levitate a biological organism so that its net weight is zero. RESULTS: We have used a superconducting magnet to assess the effect of diamagnetic levitation on the fruit fly D. melanogaster in levitation experiments that proceeded for up to 22 consecutive days. We have compared the results with those of similar experiments performed in another paradigm for microgravity simulation, the Random Positioning Machine (RPM). We observed a delay in the development of the fruit flies from embryo to adult. Microarray analysis indicated changes in overall gene expression of imagoes that developed from larvae under diamagnetic levitation, and also under simulated hypergravity conditions. Significant changes were observed in the expression of immune-, stress-, and temperature-response genes. For example, several heat shock proteins were affected. We also found that a strong magnetic field, of 16.5 Tesla, had a significant effect on the expression of these genes, independent of the effects associated with magnetically-induced levitation and hypergravity. CONCLUSIONS: Diamagnetic levitation can be used to simulate an altered effective gravity environment in which gene expression is tuned differentially in diverse Drosophila melanogaster populations including those of different age and gender. Exposure to the magnetic field per se induced similar, but weaker, changes in gene expression.

| S-EPMC3305489 | biostudies-literature

Magneto-Optical Trap Field Characterization with the Directional Hanle Effect.

Project description:We demonstrate the use of spatial emission patterns to measure magnetic fields. The directional aspect of the Hanle effect gives a direct, visual presentation of the magnetic fields, in which brighter fluorescence indicates larger fields. It can be used to determine the direction as well as the magnitude of the field. It is particularly well suited for characterizing and aligning magneto-optical traps, requiring little or no additional equipment or setup beyond what is ordinarily used in a magneto-optical trap, and being most sensitive to fields of the size typically present in a magneto-optical trap.

| S-EPMC6586866 | biostudies-literature

Multiparameter optimisation of a magneto-optical trap using deep learning.

Project description:Machine learning based on artificial neural networks has emerged as an efficient means to develop empirical models of complex systems. Cold atomic ensembles have become commonplace in laboratories around the world, however, many-body interactions give rise to complex dynamics that preclude precise analytic optimisation of the cooling and trapping process. Here, we implement a deep artificial neural network to optimise the magneto-optic cooling and trapping of neutral atomic ensembles. The solution identified by machine learning is radically different to the smoothly varying adiabatic solutions currently used. Despite this, the solutions outperform best known solutions producing higher optical densities.

| S-EPMC6195564 | biostudies-literature

Aptamer-Based Sensing of Small Organic Molecules by Measuring Levitation Coordinate of Single Microsphere in Combined Acoustic-Gravitational Field.

Project description:We present aptamer-based sensing using a coupled acoustic-gravitational (CAG) field, which transduces a change in the density of a microparticle (MP) to a change in the levitation coordinate. A large density of the MP is initially induced by the binding of gold nanoparticles (AuNPs) on the MP through sandwich hybridization with aptamer DNA molecules. Targets added to the system interact with the aptamer DNA molecules to form complexes, and the duplex between the aptamer and the probe DNA molecules is dissociated. This leads to the release of AuNPs from the MP and a decrease in its density. As the target concentration increases, the levitation coordinate of the MP increases. From the levitation coordinate shift, we can determine the target concentration. The detection limits for adenosine triphosphate, dopamine, and ampicillin as test targets are 9.8 nM, 17 nM, and 160 pM, respectively. The dissociation constants for the aptamer-target complexes are quantitatively determined from the dependence of the levitation coordinate on the target concentration. This scheme is a useful analytical tool not only for the trace analyses of targets but also for the evaluation of aptamer-target interactions.

| S-EPMC7045491 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data