Multiscale modelling of drug transport and metabolism in liver spheroids.

ABSTRACT: In early preclinical drug development, potential candidates are tested in the laboratory using isolated cells. These in vitro experiments traditionally involve cells cultured in a two-dimensional monolayer environment. However, cells cultured in three-dimensional spheroid systems have been shown to more closely resemble the functionality and morphology of cells in vivo. While the increasing usage of hepatic spheroid cultures allows for more relevant experimentation in a more realistic biological environment, the underlying physical processes of drug transport, uptake and metabolism contributing to the spatial distribution of drugs in these spheroids remain poorly understood. The development of a multiscale mathematical modelling framework describing the spatio-temporal dynami

SUBMITTER: Leedale JA 

PROVIDER: S-EPMC7061947 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature