Ontology highlight
ABSTRACT:
SUBMITTER: Lozano-Gerona J
PROVIDER: S-EPMC7062274 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lozano-Gerona Javier J Oliván-Viguera Aida A Delgado-Wicke Pablo P Singh Vikrant V Brown Brandon M BM Tapia-Casellas Elena E Pueyo Esther E Valero Marta Sofía MS Garcia-Otín Ángel-Luis ÁL Giraldo Pilar P Abarca-Lachen Edgar E Surra Joaquín C JC Osada Jesús J Hamilton Kirk L KL Raychaudhuri Siba P SP Marigil Miguel M Juarranz Ángeles Á Wulff Heike H Miura Hiroto H Gilaberte Yolanda Y Köhler Ralf R
PloS one 20200309 3
Ion channels have recently attracted attention as potential mediators of skin disease. Here, we explored the consequences of genetically encoded induction of the cell volume-regulating Ca2+-activated KCa3.1 channel (Kcnn4) for murine epidermal homeostasis. Doxycycline-treated mice harboring the KCa3.1+-transgene under the control of the reverse tetracycline-sensitive transactivator (rtTA) showed 800-fold channel overexpression above basal levels in the skin and solid KCa3.1-currents in keratinoc ...[more]