Ontology highlight
ABSTRACT:
SUBMITTER: Sterlin D
PROVIDER: S-EPMC7062531 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200301 3
In humans, several grams of IgA are secreted every day in the intestinal lumen. While only one IgA isotype exists in mice, humans secrete IgA1 and IgA2, whose respective relations with the microbiota remain elusive. We compared the binding patterns of both polyclonal IgA subclasses to commensals and glycan arrays and determined the reactivity profile of native human monoclonal IgA antibodies. While most commensals are dually targeted by IgA1 and IgA2 in the small intestine, IgA1+IgA2+ and IgA1-I ...[more]