Butler enables rapid cloud-based analysis of thousands of human genomes.
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ABSTRACT:
SUBMITTER: Yakneen S
PROVIDER: S-EPMC7062635 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Butler enables rapid cloud-based analysis of thousands of human genomes.
Yakneen Sergei S Waszak Sebastian M SM Gertz Michael M Korbel Jan O JO
Nature biotechnology 20200205 3
We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner. ...[more]
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