Butler enables rapid cloud-based analysis of thousands of human genomes.

ABSTRACT: We present Butler, a computational tool that facilitates large-scale genomic analyses on public and academic clouds. Butler includes innovative anomaly detection and self-healing functions that improve the efficiency of data processing and analysis by 43% compared with current approaches. Butler enabled processing of a 725-terabyte cancer genome dataset from the Pan-Cancer Analysis of Whole Genomes (PCAWG) project in a time-efficient and uniform manner.

SUBMITTER: Yakneen S 

PROVIDER: S-EPMC7062635 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature