Ontology highlight
ABSTRACT:
SUBMITTER: Fitzpatrick SF
PROVIDER: S-EPMC7063103 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Frontiers in physiology 20200303
The metabolic response to endotoxemia closely mimics those seen in sepsis. Here, we show that the urinary excretion of the metabolite 2-hydroxyglutarate (2HG) is dramatically suppressed following lipopolysaccharide (LPS) administration <i>in vivo</i>, and in human septic patients. We further show that enhanced activation of the enzymes responsible for 2-HG degradation, D- and L-2-HGDH, underlie this effect. To determine the role of supplementation with 2HG, we carried out co-administration of LP ...[more]