Ontology highlight
ABSTRACT:
SUBMITTER: Moukengue B
PROVIDER: S-EPMC7063190 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Moukengue Brice B Brown Hannah K HK Charrier Céline C Battaglia Séverine S Baud'huin Marc M Quillard Thibaut T Pham Therese M TM Pateras Ioannis S IS Gorgoulis Vassilis G VG Helleday Thomas T Heymann Dominique D Berglund Ulrika Warpman UW Ory Benjamin B Lamoureux Francois F
EBioMedicine 20200307
<h4>Background</h4>Osteosarcoma (OS) is the most common primary malignant bone tumour. Unfortunately, no new treatments are approved and over the last 30 years the survival rate remains only 30% at 5 years for poor responders justifying an urgent need of new therapies. The Mutt homolog 1 (MTH1) enzyme prevents incorporation of oxidized nucleotides into DNA and recently developed MTH1 inhibitors may offer therapeutic potential as MTH1 is overexpressed in various cancers.<h4>Methods</h4>The aim of ...[more]