Fc-Linked IgG N-Glycosylation in Fc?R Knock-Out Mice.
Ontology highlight
ABSTRACT:
SUBMITTER: Zaytseva OO
PROVIDER: S-EPMC7063467 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Fc-Linked IgG <i>N</i>-Glycosylation in FcγR Knock-Out Mice.
Zaytseva Olga O OO Seeling Michaela M Krištić Jasminka J Lauc Gordan G Pezer Marija M Nimmerjahn Falk F
Frontiers in cell and developmental biology 20200303
Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases. Glycosylation of the IgG fragment crystallizable (Fc) region is shown to vary in different physiological and pathological states. Fc <i>N</i>-glycan composition can alter the effector functions of IgG by modulating its affinity for ligands, such as Fcγ receptors (FcγRs). However, it is not known whether IgG glycosylation is affected by the avail ...[more]
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