Ontology highlight
ABSTRACT:
SUBMITTER: Duong T
PROVIDER: S-EPMC7063671 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Duong Tam T Rasmussen Neal R NR Ballato Elliot E Mote F Sefakor FS Reiner David J DJ
Development (Cambridge, England) 20200302 5
In many eukaryotes, the small GTPase Rheb functions as a switch to toggle activity of TOR complex 1 (TORC1) between anabolism and catabolism, thus controlling lifespan, development and autophagy. Our CRISPR-generated, fluorescently tagged endogenous <i>Caenorhabditis elegans</i> RHEB-1 and DAF-15/Raptor are expressed ubiquitously and localize to lysosomes. LET-363/TOR and DAF-15/Raptor are required for development beyond the third larval stage (L3). We observed that deletion of RHEB-1 similarly ...[more]