The lymph node at a glance - how spatial organization optimizes the immune response.
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ABSTRACT:
SUBMITTER: Grant SM
PROVIDER: S-EPMC7063836 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
The lymph node at a glance - how spatial organization optimizes the immune response.
Grant Spencer M SM Lou Meng M Yao Li L Germain Ronald N RN Radtke Andrea J AJ
Journal of cell science 20200306 5
A hallmark of the mammalian immune system is its ability to respond efficiently to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore, a robust immune response requires the coordination of a diverse range of cells present at low frequencies within the host. This problem is solved, in part, by concentrating antigens, antigen-presenting cells and antigen-responsive cells in lymph nodes (LNs). Beyond housing these cell types in one location, LNs are highly or ...[more]
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