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Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation.

ABSTRACT: The resorcylic macrolides are important natural products with a wide range of remarkable biological activities. So far, most of the reported resorcylic macrolide syntheses use either macrolactonization or ring closing metathesis to build the corresponding macrocycle. In continuation of our efforts in developing novel carbonylation reactions to facilitate natural product total synthesis, we report herein a total synthesis of trans-resorcylide (1) featuring a palladium-catalyzed macrocyclic Stille carbonylation to build its 12-membered macrocycle.

SUBMITTER: Luo Y

PROVIDER: S-EPMC7063981 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature

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Total Synthesis of trans-Resorcylide via Macrocyclic Stille Carbonylation.

Luo Yiyang Y Yin Xianglin X Dai Mingji M

The Journal of antibiotics 20190213 6

The resorcylic macrolides are important natural products with a wide range of remarkable biological activities. So far, most of the reported resorcylic macrolide syntheses use either macrolactonization or ring closing metathesis to build the corresponding macrocycle. In continuation of our efforts in developing novel carbonylation reactions to facilitate natural product total synthesis, we report herein a total synthesis of trans-resorcylide (1) featuring a palladium-catalyzed macrocyclic Stille ...[more]

PMID: 30760840

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