Postoperative standard chemoradiotherapy benefits primary glioblastoma patients of all ages.

ABSTRACT:

Background

Glioblastoma is the most malignant tumor of the central nervous system. Several prediction models have been produced to aid in prognosis assessment. Age, a primary decision factor for prognosis, is associated with increased genomic alterations, however the exact link between increased age and poor prognosis is unknown.

Objective

In this study, we aimed to reveal the underlying cause of poor prognosis in elderly patients.

Methods

This study included data on 616 primary GBM tumor samples from the CGGA and TCGA databases and 41 nontumor brain tissue samples obtained from GSE53890. Hallmarks and clinicopathological characteristics were evaluated in both tumor and nontumor brain tissues. The association between choice of treatment regimen and age was measured us

SUBMITTER: Li G 

PROVIDER: S-EPMC7064041 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature