Elevated HbA1c Is Associated with Altered Cortical and Trabecular Microarchitecture in Girls with Type 1 Diabetes.

ABSTRACT:

Context

Skeletal fragility is a significant complication of type 1 diabetes (T1D), with an increased risk of fracture observed starting in childhood. Altered bone accrual and microarchitectural development during the critical peripubertal years may contribute to this fragility.

Objective

To evaluate differences in skeletal microarchitecture between girls with T1D and controls and to assess factors associated with these differences.

Design

Cross-sectional comparison.

Participants

Girls ages 10-16 years, 62 with T1D and 61 controls.

Results

Areal bone mineral density (BMD) measured by dual-energy x-ray absorptiometry did not differ between girls with and without T1D. At the distal tibia, trabecular BMD was 7.3 ± 2.9% lower in T1D (P = 0.013), with fewer pl

SUBMITTER: Mitchell DM 

PROVIDER: S-EPMC7064304 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature