Ontology highlight
ABSTRACT:
SUBMITTER: Jain P
PROVIDER: S-EPMC7064337 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
eLife 20200310
The Polycomb-like protein PHF19/PCL3 associates with PRC2 and mediates its recruitment to chromatin in embryonic stem cells. PHF19 is also overexpressed in many cancers. However, neither PHF19 targets nor misregulated pathways involving PHF19 are known. Here, we investigate the role of PHF19 in prostate cancer cells. We find that PHF19 interacts with PRC2 and binds to PRC2 targets on chromatin. PHF19 target genes are involved in proliferation, differentiation, angiogenesis, and extracellular mat ...[more]