Ontology highlight
ABSTRACT:
SUBMITTER: Kuhlen L
PROVIDER: S-EPMC7064499 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Kuhlen Lucas L Johnson Steven S Zeitler Andreas A Bäurle Sandra S Deme Justin C JC Caesar Joseph J E JJE Debo Rebecca R Fisher Joseph J Wagner Samuel S Lea Susan M SM
Nature communications 20200310 1
Protein secretion through type-three secretion systems (T3SS) is critical for motility and virulence of many bacteria. Proteins are transported through an export gate containing three proteins (FliPQR in flagella, SctRST in virulence systems). A fourth essential T3SS protein (FlhB/SctU) functions to "switch" secretion substrate specificity once the growing hook/needle reach their determined length. Here, we present the cryo-electron microscopy structure of an export gate containing the switch pr ...[more]